1: Sb Lek. 2003;104(4):375-85.
-
[Microsleep from the electro- and psychophysiological point of view]
[Article in Czech]
Faber J, Novak M, Svoboda P, Tatarinov V, Tichy T.
Laborator spolehlivosti systemu, Dopravni fakulta, Ceske vysoke uceni technicke
Konviktska 20, 110 00 Praha 1.
Impaired wakefulness in machine operators poses a danger not only to themselves
but often also to the public at large. While on duty, such persons are expected
to be continuously, i.e., without interruption, on the alert. For that purpose,
we designed and carried out an experimental model of continuous vigilance
monitoring using electroencephalography (EEG) and reaction time measured
as the latency of the proband's reaction to sound. If constructed, the set
together with other logical elements and an alarm can make for an automatic
detection of vigilance and, possibly, also of arousal stimuli in cases of
microsleep. We found the following new facts and confirmed the validity of
some of the earlier ones: Vigilance is marked by alpha activity in the EEG
record (oscillation of 8-13 Hz) and reaction time (RT) of 200-400 ms (milliseconds).
Sleep is characterized by theta and delta activities (4-7 and 0.5-3.5 Hz
respectively) with no reaction. Between wakefulness and sleep there are at
least two stages: relaxation with prolonged RT of 400 to 800 ms and increased
EEG alpha, sometimes also beta activities. Then there is the hypnagogic phase
with disintegrating alpha and growing theta or even delta activities and
an RT of 800 up to 1200 ms. Changes in the EEG and its spectrum and their
actual localization on the cranial surface exhibit individual differences;
hence, no straightforward categories for the above stages can be established.
As for changes in vigilance in the relaxation and hypnagogic phases as well
as in the processes of mentation, the most significant are the alpha and
delta, less so the theta and beta bands. The most suitable sites for the
detection of those changes on the skull surface are temporo-parieto-occipital
(TPO) regions, i.e., those over the posterior parts of the skull with the
least muscle and oculomotor artifacts and with the most energy for alpha
and delta activities. In somnolence, the cortex does not behave as a whole,
which means that different areas show different spectra while getting off
to sleep, a fact easy to express by means of the alpha/delta ratio, separately
for each of the cranial areas. At sleep onset, the alpha/delta ratio undergoes
changes; it is greater than one in wakefulness, less than one in sleep, and
in the region of one as the person goes to sleep. In the course of sleep
with zero reactivity, the cortex already behaves as a whole, i.e., all cranial
areas have similar or the same spectrograms, with the alpha/delta coefficient
being less than one all over the skull. At times, the spectrogram taken during
mentation (e.g., while undergoing psychological tests) resembles that of
somnolence, with the alpha/delta coefficient being greater than one. However,
there are differences: in somnolence, the delta activity is increased all
over its band, i.e., from 0.5 to 3.5 Hz, while during mentation it is increased
solely in the slow delta activity band (0.5 to 3.5 Hz). In somnolence, theta
is on the increase, but not so in mentation. In the hypnagogic phase, alpha
becomes completely extinct--unlike in mentation. As follows from the above
listed facts, not everyone applying for an automatic alarm detector of vigilance
can be provided with one at random and expect it to go off at the first sign
of slumber. Conversely, every applicant ought to be treated as a proband,
i.e., tested with simultaneous EEG registration, EEG analysis, determination
of the best suitable area on the cranial surface and EEG frequency, separately
for vigilance, relaxation, hypnagogic phase and mentation, and--in keeping
with the above rules--have individual parameters of the alarm device adjusted
accordingly.
PMID: 15320529 [PubMed - in process]
2: Sb Lek. 2000;101(3):233-9.
The influence of traumatic brain lesion on sleep architecture.
Busek P, Faber J.
Neurological Clinic, 1st Medical Faculty of Charles University, Katerinska
30, 120 00 Prague, Czech Republic.
The authors deal with sleep changes in patients after brain injury. Ten patients
were examined with the use of daytime routine EEG and night polysomnography.
The amount of REM sleep is most sensitive to brain damage and is reduced
in all patients with nonspecific epileptiform changes in the EEG. Changes
in deep synchronous sleep are less frequent and are not in correlation with
the prevalence of epileptiform changes. Thus the reduction of REM sleep seems
to be a sensitive marker of development of epileptiform EEG-changes and perhaps
could play a predictive role of development of post-traumatic epilepsy.
PMID: 11220151 [PubMed - indexed for MEDLINE]
3: Sb Lek. 1999;100(4):309-13.
[EEG findings in patients with systemic lupus erythematosus]
[Article in Czech]
Peterova V, Faber J, Dostal C, Seidl Z, Obenberger J, Vitak T, Danes J,
Olejarova M.
Radiodiagnosticka klinika-Odd. magneticke resonance, Vseobecne fakultni nemocnice
v Praze a 1. lekarske fakulty Univerzity Karlovy, Czech Republic.
We have examined electroencephalography (EEG) and Mini-Mental State Examination
(MMSE) in 38 patients with verified diagnosis of systemic lupus erythematosus
(SLE). In the clinical neurological finding there were epileptic attacks
in 9 patients, 10 patients suffered from stroke, 15 patients from lupus headache,
4 patients from psychosis, in 15 patients cranial neuropathy was present,
in one person extrapyramidal syndrome. EEG findings were in 12 patients normal
(32%), in 26 patients abnormal (66%). In 3 cases there were focal abnormalities
(8%), in 19 cases episodic ones (48%), four times abnormalities were diffuse
(10%). Diffuse abnormalities correlated in EEG findings with case history
of GM attacks.
PMID: 11221481 [PubMed - indexed for MEDLINE]
4: Sb Lek. 1999;100(3):191-204.
EEG spectrum as information carrier.
Faber J, Srutova L, Pilarova M, Vuckova Z, Bohmova D, Dobosova L.
Department of Neurology, 1st Faculty of Medicine, Charles University, Katerinska
30, 120 00 Prague 2, Czech Republic.
Spontaneous and provoked changes of vigilance and consciousness are determined
by TCS (thalamocortical system) activity. This is relatively easy to monitor
using EEG, which is a complex curve but open to analysis, e.g., by means
of FFT (fast Fourier transformation). Twenty six persons (six normal controls,
twelve epileptics, eight dements) had EEG recorded during rest, reaction
to sound, and perception to simple tones or chords from Smetana's symphonic
poem Vysehrad. The length of reaction time was found dependent on FFT changes:
the longer the time, the higher are the delta and the lower the alpha activities
in the EEG spectrum. However, with alpha increasing during relaxation, the
reaction time grew longer regardless of whether delta had increased due to
hyperventilation, sleep or subclinical epileptic discharges. During the perception
of tones, FFT showed changes in the alpha and delta bands different from
those during the perception of chords, and different again during relaxation,
and that in both normal controls and epileptics. The demented persons revealed
no discernible FFT differences in the perception of either tones or chords,
the only differences were found in the resting sections of the spectrum.
One and the same stimulus produced a stereotype FFT response, i.e., different
stimuli elicited different FFT response in healthy and epileptic persons.
The dements responded to identical stimuli differently, and had stereotype
FFT response elicited by the same stimuli. The results suggest that FFT can
represent the information content of the EEG curve and, indirectly, also
that of micro-EEG as it reverberates between the thalamus and the cortex
in the form of neuronal activity impulsations. This interneuronal impulsation
coding is disordered in dements with atrophy of the cortex; it is marked,
on the one hand, by increased variability in the perception of identical
stimuli, and, on the other hand, by impaired differentiation, and, consequently,
by increasingly stereotype responses to different stimuli.
PMID: 11221466 [PubMed - indexed for MEDLINE]
5: Sb Lek. 1999;100(2):125-38.
[Aenigma sensorii or the mystery of human consciousness]
[Article in Czech]
Faber J.
Neurologicka klinika 1. LF UK, Katerinska 30, 121 08 Praha 2, Czech Republic.
Publication Types:
PMID: 11220162 [PubMed - indexed for MEDLINE]
6: Sb Lek. 1997;98(3):249-50.
[Thoughts on the impact factor]
[Article in Czech]
Faber J.
Neurologicka klinika 1. lekarske fakulty Univerzity Karlovy.
PMID: 9601820 [PubMed - indexed for MEDLINE]
7: Sb Lek. 1996;97(1):71-95.
"Epileptosis"--a syndrome or useless speculation?
Faber J, Vladyka V, Dufkova D, Faltus F, Jirak R, Pavlovsky P, Smidova
E, Zvolsky P, Zukov I, Klar I, Posmurova M, Srutova L.
Neurological Department, 1st Faculty of Medicine, Charles University; Prague,
Czech Republic.
102 patients were divided into 3 groups: epileptics, psychotics and epileptics
with psychotic symptoms. All had long been monitored for a number of clinical
and laboratory parameters. Though different in many respects, all share states
of sudden dysphoria, cacophoria, panic anxiety, horror, and EEG (stereo-EEG,
too) signs of epileptic or other gross anomalies, often correlated to those
affective disorders. Attacks of dysphoria, epilepsy, and psychosis come spontaneously
and in response to biological (hypoglycemia, sleep deprivation, alcohol,
menses) or psychosocial stimulation (agitation, quarrels, fear of redundancy,
psychic trauma). These states (attacks, dysphoria, "neurotic" or
even psychotic episodes) often provoke one another. -Calling this syndrome
epileptosis, we believe its mechanism is due to lesions of the limbic and
brainstem modulation systems. At the start of the process there is an epileptic
focus in the amygdalo-hippocampal complex (AHC) which in itself can trigger
simple or complex partial paroxysm but also-by means of electric stimulation
of the AHC-states of dysphoria, anxiety, and psychotic hallucinations. Besides,
a form of pathological learning develops in premorbid "hypersensitive" personality
which can be put down to associative learning and to Overton's phenomenon
of "state-dependent retention of learned responses". This may give
rise to mutual stimulation where epileptic focal activity in AHC can provoke
dysphoria while an external psychosocial situation can trigger epileptic
activity there, too (AHC). Since there need not always be mydriasis (though
other vegetative signs such as tachycardia, tachypnoea, nausea, blush and
others are frequent) or unconsciousness, and some psychomotor manifestations
may be out of the ordinary, and scalp EEG may be normal, such patients are
often regarded as "hysterics" or malingerers.
PMID: 8711419 [PubMed - indexed for MEDLINE]
8: Harefuah. 1995 Sep;129(5-6):197-200.
[Relationship between sleeping position and sudden
infant death syndrome]
[Article in Hebrew]
Eidelman A, Faber J.
Publication Types:
PMID: 8543261 [PubMed - indexed for MEDLINE]
9: Cesk Psychiatr. 1993 Jun;89(3):130-47.
[Detection of cerebropathy in neurologic and psychiatric
diseases]
[Article in Czech]
Faber J, Vladyka V, Subrt O, Kvasnicka J, Preiss J, Masopust J, Michalova
K, Jirak R, Bakos K, Vitak J, et al.
Neurologicka klinika 1. lekarske fakulty Univerzity Karlovy, Praha.
The authors made a comprehensive examination of 16 patients--epileptics,
alcoholics, psychotic subjects and patients after cerebral contusion. The
patients were subjected to a neurological, psychiatric, psychological examination
as well as to a morphological examination (X-ray, CT, NMR), physiological
examination (EEG, polysomnography, evoked potentials), immunological examination
and SPECT. The majority of patients had positive CT and SPECT findings suggesting
focal brain damage. These results could be explained only in exceptional
cases by injury, the majority was of unknown aetiology. With this corresponded
focal EEG abnormalities and in particular sleep disorders, sometimes subjective
but always detectable by objective methods. There was always a shortage of
REM, sometimes also NONREM sleep. Half the patients were subjected to an
immunological examination which was always positive and comprised elevated
acute stage proteins and proteins associated with the stress reaction. Numerous
data in the literature and the authors' experience indicate that the mentioned
pathological findings are not incidental and form, independently on the aetiology,
an integrated unit for which the term cerebropathy can be used. A primary
role is played by the epileptic focus and its quality, i.e. above all the
rate of discharge and site and humoroergic systems of the brain stem, in
particular their efficiency and mutual balance. The events have a programmed
sequence. At the beginning an epileptic focus develops which influences the
surrounding area, secondary and tertiary foci are formed and the thalamo-cortical
system is affected. Soon this is followed by an apparent influence of the
epileptic activity on structures of the brain-stem. The consequence are changes
affecting sleep, mood, mental performance, immunity, endosecretion and paroxysms.
Subsequently individual symptoms are already prepared but have a different
latency of manifestation and the latter depends also on external provoking
influences. The thalamo-cortical reaction is characterized by the manifestation
of epileptic paroxysms and sets in after a different interindividual incubation
following injury. The same applies to the hippocampal reaction manifested
by the organic psychosyndrome. Some symptoms such as changes of immunity,
sleep or endosecretory function are not necessarily manifested if the influence
of the focus on structures of the brain-stem is not sufficiently intense.
Conversely if the effect on the brain-stem and limbic structures is greater
and the effect on the thalamo-cortical system smaller, psychotiform behaviour
develops. Then there are marked changes of phoria, dynamogeny, rate, affectivity,
sleep and hormonal secretion and its equilibrium.
PMID: 8353828 [PubMed - indexed for MEDLINE]
10: Sb Lek. 1993;94(1):81-94.
Neurohumoral relations in neurological and psychiatric
patients.
Faber J, Vladyka V, Subrt O, Kvasnicka J, Preiss J, Masopust J, Michalova
K, Jirak R, Bakos K, Vitak J, et al.
Neurological Department, 1st Medical Faculty, Charles University, Prague,
Czech Republic.
Sixteen patients-epileptics, alcoholics, psychotics and post-contusion cases-were
subjected to neurological, psychiatric, psychological, morphological (X-ray,
CT, NMR), physiological (EEG, polysomnography, evoked potentials), immunological
and SPECT examination. Most had CT and SPECT signs of focal brain damage.
The results were but exceptionally due to injury, most were of unknown etiology.
This tallied with EEG focal abnormalities, mainly sleep disorders, sometimes
subjective ones, but invariably detectable objectively. In each case there
was REM, in some also NONREM sleep deficiency. Half of the cases were tested
immunologically, each time with positive results: increased levels of acute-phase
protein and stress-reaction proteins. As copious literature and our experience
show, the above pathological condition, rather than being accidental, constitute
regardless of etiology, an integrated entity which could be called "programme
cerebropathy". The primary role is played there by the epileptic focus
and its properties, in particular, the speed of discharge and localization
and brain stem humoroergic systems, i.e., their performance and mutual balance.
There is a program sequence of events, first, and epileptic focus acting
on the neighborhood, the rise of secondary and tertiary foci, and influence
over the thalamocortical system. Soon afterwards, epileptic activity begins
to act on brain-stem structures. This results in changes in sleep, mood,
psychic output, immunity, endosecretion, and in paroxysms.
PMID: 7992003 [PubMed - indexed for MEDLINE]
11: Cesk Psychiatr. 1991 Nov;87(3-4):151-67.
[Nonstandard therapy of epileptics and psychotics]
[Article in Czech]
Faber J, Havlova M.
Neurologicka klinika 1. lekarske fakulty KU, Praha.
The authors present their experience with a number of drugs which are not
antiepileptics nor antipsychotic drugs but influence the cholinergic and
noradrenergic system and glucose and protein metabolism of neurons. Their
efficiency in severe epileptics with psychic changes is about 60%. Standard
epileptic treatment, mono- and polytherapy, failed completely in these patients.
To the authors' "modulating" and "nootropic" therapy
applies the same what applies to stereotactic treatment of epilepsy, i.e.
that treatment must be started before the epileptic or psychotic process
becomes chronic. Epileptogenesis is divided into the following stages: 1.
insulation of the brain and development of a lesion (trauma, asphyxia, infection),
2. A. latency, an epileptic focus develops in the lesion, 2. B. latency,
secondary and tertiary epileptic foci develop, in particular in the corpus
amygdaloideum, hippocampus and fronto-orbital area and from there frequently
also psychic changes arise, 2. C. the focus acts also on the thalamo-cortical
reverbation circle and gradually "teaches" it epileptic discharges
which sometimes can be followed on the EEG, although this stage is still
in the latent period, i.e. clinically inapparent. 2. D. modulating structures
of the stem fail, REM, i.e. paradox sleep, diminishes. Because these stages
resemble those in the development of some psychoses, the psychogenesis of
this epileptogenesis is similar; in schizophrenia the deepest stage of NONREM
sleep declines. In this stage of epilepsy the inhibitory protective influence
of noradrenergic, serotoninergic and dopaminergic (?) systems disappears.
The 3rd stage is manifestation of clinical attacks or psychotic behaviour
which may be enhanced by some provocation, e.g. alcohol, sleep deprivation,
psychic stress, which influence emotivity and the sleep profile. With regard
to these stages (insulation, latency, manifestation) treatment should be
provided. In the 1st and 2nd stage "nootropic and modulating" treatment
should be administered to a greater extent.
PMID: 1822417 [PubMed - indexed for MEDLINE]
12: Sb Lek. 1991 Aug;93(7-8):239-48.
[Consciousness and the electroencephalogram]
[Article in Czech]
Faber J, Vladyka V, Subrt O.
Neurologicka klinika 1. lekarske fakulty Univerzity Karlovy, Praha.
In the course of 12 years the authors subjected to clinical EEG and stereo-EEG
(SEEG) 72 patients (66 epileptics with the diagnosis of psychomotor epilepsy
and grand mal) and six psychotic patients suffering from schizophrenia. With
the exception of five epileptics and two psychotic patients all subjects
had epileptic foci in the amygdalohippocampal complex (AHK). After coagulation
of these foci marked improvement of the fits and the mental state occurred
in half the patients. During EEG and SEEG recording the authors used different
activation methods (hyperventilation through the nose and mouth, sleep, listening
to music) and above all direct electric stimulation (ES) of one of the AHK.
Secondary epileptic foci had, as a rule, more spikes and a lower threshold
for ES than primary ones which contained more delta and slow theta waves.
The ES led as a rule to an emotional response, such as anxiety and fear,
more rarely to illusions, depersonalization and oneiroid hallucinations and
twice to a hedonic response of non-sexual character. The purpose of ES was
to assess the site from where it is possible to start the original aura or
typical parox. The authors considered these foci, consistent with data in
the literature, as the leading focus and it was subsequently coagulated.
The authors investigated the reactivity and vigility by the patient's response
to sound (the patient had to press a button) and by an interview with the
patient. It was revealed that in isolated discharges of the spikes and waves
in the scalp electrodes, i.e. in the neocortex, reactivity is lacking. In
isolated discharges in the AHK the reactivity was satisfactory, but as a
rule anxiety developed. It is thus possible to divide consciousness into
emotional consciousness with its site in the AHK, i.e. in the limbic system,
and rational consciousness which is a function of the neocrotical system.
Congenital changes of consciousness such as vigility or sleep are described
as "states" of consciousness. The rational or emotional aspect
of behaviour is described as "type" of consciousness. Under normal
conditions the states of consciousness alternate periodically and are sharply
defined, the types of consciousness are closely linked and are difficult
to separate. Under pathological conditions the "states" of consciousness
differ less markedly and the "types" of consciousness are in dissociation.
Thus obnubilation, depersonalization, illusions, pathic affects etc. develop,
as a rule as part of the epileptiform or psychotiform syndrome.
Publication Types:
PMID: 1754832 [PubMed - indexed for MEDLINE]
13: Dev Med Child Neurol. 1990 Sep;32(9):792-5.
Hemiparetic forms of cerebral palsy in relation to
epilepsy and mental retardation.
Sussova J, Seidl Z, Faber J.
Department of Neurology, Charles University, Praha 2, Czechoslovakia.
Fifty-one children with hemiparetic cerebral palsy underwent clinical, EEG
and CT examinations to assess mental performance, laterality of CP and incidence
of epilepsy, 80 per cent of the children had epileptic abnormalities on EEG,
but less than half had clinical signs of epilepsy. Clinical paroxysms were
more frequent in those with right-sided hemiparesis. Focal or epileptic EEG
changes were usual in those with right-hemisphere involvement, but unless
clinical paroxysms developed, these had no bearing on mental performance.
Lower IQ was found in the patients with clinical epilepsy--in nearly all
cases with left-sided hemiparesis and in half of those with right-sided hemiparesis.
PMID: 2121572 [PubMed - indexed for MEDLINE]
14: Acta Univ Carol [Med] (Praha). 1988;34(3-4):149-248.
Thalamocortical reverberation circuit simulation using
the simula language.
Faber J, Weinberger J.
PMID: 3273848 [PubMed - indexed for MEDLINE]
15: Neurology. 1987 Jun;37(6):1046-50.
Familial progressive neuronal disease and chronic
idiopathic intestinal pseudo-obstruction.
Steiner I, Steinberg A, Argov Z, Faber J, Fich A, Gilai A.
Chronic idiopathic intestinal pseudo-obstruction (CIIP) is characterized
by recurrent episodes of bowel obstruction without mechanical cause. In five
members of two Jewish-Iranian families, CIIP was associated with progressive
neuronal disease, starting before age 30, with ophthalmoplegia, sensorimotor
peripheral neuropathy, and hearing loss. There was no evidence of CNS involvement.
The pattern suggested autosomal recessive inheritance.
Publication Types:
PMID: 3035426 [PubMed - indexed for MEDLINE]
16: Cas Lek Cesk. 1987 May 15;126(20):631-4.
[The electroencephalogram and stereo-electroencephalogram
in epileptic and psychotic patients]
[Article in Czech]
Faber J, Vladyka V.
PMID: 3297345 [PubMed - indexed for MEDLINE]
17: Cesk Psychiatr. 1987 Apr;83(2):83-91.
[Interpretation of the electroencephalogram in psychotics]
[Article in Czech]
Faber J, Vladyka V, Smolik P, Tausigova D.
PMID: 3581263 [PubMed - indexed for MEDLINE]
18: Acta Univ Carol [Med] (Praha). 1987;33(3-4):245-310.
Epileptogenesis and "psychosogenesis", antithesis
or synthesis?
Faber J, Vladyka V.
PMID: 3453007 [PubMed - indexed for MEDLINE]
19: Cesk Psychiatr. 1986 Apr;82(2):91-6.
[Electroencephalographic analysis during a psychological
test in normal and psychotic individuals]
[Article in Czech]
Faber J, Probstova V, Ganicky P, Smolik P, Paroubkova D, Nohacova E, Zdrahal
Z, Marik V, Skarolek V, Rajsky J, et al.
PMID: 3731313 [PubMed - indexed for MEDLINE]
20: Acta Univ Carol Med Monogr. 1984;108:1-145.
Nocturnal sleep stereo-electroencephalography and
polygraphy in epileptics.
Faber J, Vladyka V.
Focal epileptic activity (FEA) in amygdalohippocampal complexes (AHC) is
mostly highly intensive (except in patient BUK where it is nearly missing).
Unilateral FEA is hardly ever propagated to the superficial EEG electrodes,
bilateral FEA only very rarely (patients BRY and DUS), in some patients solely
in deep synchronous sleep (patient LOB). FEA intensity rises in relaxed vigilance
and in superficial sleep while tending to decrease in deep synchronous sleep.
FEA intensity tends to drop or even disappear in active vigilance during
mental activity or paradoxical sleep. Epileptic activity generalized in all
the superficial and deep-implanted leads is mostly accompanied by clinical
manifestations (absences, twitching, motor automatisms), or to put it the
other way round: if a clinical paroxysms is in progress, there is evidence
of generalized epileptic activity in all the leads. The time parameter is
of no consequence, the inconspicuous motion of the hand is due to a second-lasting
discharge of polyspike and wave (patient BRY in sleep). If prolonged discharges
remain localized there is subclinical paroxysm (patient IRL). Similar findings
were reported by Lieb et al. (1976). All we can add is that the start of
an attack depends not only on the amplitude and frequency of the spikes but
also on the regularity of spike intervals. Superficial "neocortical" EEG
and deep "paleocortical" SEEG exhibit equal sleep stages equally,
i.e. either there is synchronization in all the leads (like in synchronous
sleep), or there is desynchronization (such as in active vigilance or in
paradoxical sleep); those two cortical structures are not antithetical such
as in, e.g., rats or cats. The sleep stages show quantitative as well as
qualitative changes. There is increasingly more wakefulness and superficial
sleep at the expense of spindle and paradoxical sleep. EEG graphoelements
often show little differentiation, e.g. the sleep spindles are short and
irregular in shape, delta activity is low in amplitude and also irregular
in shape, and paradoxical sleep shows insufficient desynchronization in EEG
and preserved tonic muscular activity. Epileptic activity variability is
often found helpful for the reliable identification of the sleep stage concerned.(ABSTRACT
TRUNCATED AT 400 WORDS)
PMID: 6399435 [PubMed - indexed for MEDLINE]
21: Act Nerv Super (Praha). 1983 Dec;25(4):304-8.
Antiepileptic effect of electric stimulation of the
locus coeruleus in man.
Faber J, Vladyka V.
Publication Types:
PMID: 6421077 [PubMed - indexed for MEDLINE]
22: Cas Lek Cesk. 1983 Jan 21;122(3):67-73.
[Electroencephalogram analysis during psychological
tests]
[Article in Czech]
Faber J, Tuhacek M, Hynek K, Sagova V, Kramarova D, Psenickova J, Vedralova
J, Teichmanova Z.
PMID: 6825143 [PubMed - indexed for MEDLINE]
23: Cas Lek Cesk. 1982 Feb 12;121(6):167-9.
[Inconsistent findings between electroencephalography
and computerized axial tomography (author's transl)]
[Article in Czech]
Seidl Z, Faber J.
PMID: 7060074 [PubMed - indexed for MEDLINE]
24: Act Nerv Super (Praha). 1981 Jun;23(2):169-71.
Differential effect of REM stimulating and REM inhibiting drugs (reserpine
and amitriptylin) on memory.
Faber J, Havrdova Z.
PMID: 7270024 [PubMed - indexed for MEDLINE]
25: Cesk Psychiatr. 1980 Jun;76(3):151-5.
[Effect of drugs on memory and the metabolism of methionine in the brain
(author's transl)]
[Article in Czech]
Faber J, Havrdova Z, Kvicala V.
Publication Types:
PMID: 7000384 [PubMed - indexed for MEDLINE]
26: Act Nerv Super (Praha). 1979 Mar;21(1):41.
Yoga meditation effect on the EEG and EMG activity.
Dostalek C, Faber J, Krasa H, Roldan E, Vele F.
PMID: 433543 [PubMed - indexed for MEDLINE]
27: Cesk Neurol Neurochir. 1978 Jul;41(4):254-60.
[The effect of learning on the activity of administered methionine in
the brain]
[Article in Czech]
Faber J, Kvicala V, Sagova V, Dvorakova Z, Mikulenkova E.
PMID: 668012 [PubMed - indexed for MEDLINE]
28: Acta Univ Carol Med Monogr. 1978;(87):1-92.
Vigilance, sleep, petit mal and electroencephalogram as manifestations
of programmed brain regulation.
Faber J.
Publication Types:
PMID: 121865 [PubMed - indexed for MEDLINE]
29: Act Nerv Super (Praha). 1977 Sep;19(3):210.
EEG periodogram during waking, synchronized sleep and petit mal attack
[proceedings]
Faber J, Dusek J, Tosovsky J, Taichmanova Z.
PMID: 411318 [PubMed - indexed for MEDLINE]
30: Cesk Neurol Neurochir. 1977 Sep;40(5):345-9.
[Analysis of the EEG and its prognostic significance in epileptic children]
[Article in Czech]
Havlova M, Faber J, Toichmanova Z.
PMID: 908087 [PubMed - indexed for MEDLINE]
31: Cas Lek Cesk. 1976 Jun 18;115(24):713-8.
[An attempt at determining the information content of electroencephalogram
(author's transl)]
[Article in Czech]
Faber J, Dusek J, Taichmanova Z, Tuhacek M.
PMID: 954026 [PubMed - indexed for MEDLINE]
32: Cesk Fysiol. 1976;25(1):63-6.
[Vigilance and petit mal paroxysms from the viewpoint of analytical electroencephalography]
[Article in Czech]
Vymazal J, Faber J.
PMID: 815008 [PubMed - indexed for MEDLINE]
33: Cesk Neurol Neurochir. 1975 Dec;38(6):351-6.
[Analysis of electroencephalogram during vigilance and petit mal by means
of periodogram]
[Article in Czech]
Faber J, Tosovsky J, Dusek J, Taichmanova Z, Faberova V.
PMID: 811362 [PubMed - indexed for MEDLINE]
34: Electroencephalogr Clin Neurophysiol. 1975 Oct;39(4):441.
Proceedings: EEG analysis during different change of consciousness.
Faber J, Dusek J, Tosovsky J, Taichmanova Z.
PMID: 51787 [PubMed - indexed for MEDLINE]
35: Electroencephalogr Clin Neurophysiol. 1975 Oct;39(4):438.
Proceedings: Prognostic significance of EEG analysis in epileptic children.
Havlova M, Faber J.
PMID: 51774 [PubMed - indexed for MEDLINE]
36: Cesk Neurol Neurochir. 1975 Sep;38(5):260-8.
[Statistical analysis of anamnesis in disseminated sclerosis]
[Article in Czech]
Vymazal J, Tuhacek M, Hermanova H, Josifko M, Faber J.
PMID: 1181041 [PubMed - indexed for MEDLINE]
37: Act Nerv Super (Praha). 1975 May;17(2):139-43.
Factor analysis of EEG in healthy and diseased subjects.
Faber J, Tosovsky J, Hynek K, Dusek J.
Factor analysis was applied to EEG recordings of healthy and diseased subjects
to be analyzed by an "on line" broad-band frequency analyser. Differences
between the healthy and the diseased as to the number of given factors were
established by means of the Lawly test. Up to 6 factors were determined for
patients, up to 3 for the healthy. On medication, the number of factors rose
in the delta and beta bands, remaining unchanged in the alpha band dropping
the theta band. The patients manifested a sort of interindividual uniformity
and intraindividual simplification. Except for different sites of pathological
foci, the patients' EEG recordings were more like each other than those of
healthy subjects. The latter might have undergone a similar process on medication.
This enabled to establish more factors in the patients, moreover in such a
way as to expose some general laws of cortical electric activity, such as unified
cortical activity despite its various facets, hemispheral specificity, and
finally also a relative autonomy of the frontal lobes.
PMID: 1166759 [PubMed - indexed for MEDLINE]
38: Act Nerv Super (Praha). 1975 May;17(2):134-8.
Correlation of spike intervals and amplitudes in hypersynchronous EEG
episodes in rat with cobalt focus.
Chocholova L, Faber J, Taichmanova Z.
EEG activity was recorded from rats with chronic cobalt foci and implanted
electrodes. Within this activity, hypersynchronous rhythmic spike episodes
(and those of waves) of mean frequency of 8-9/sec were studied. The spike amplitude-interval
relationship was assessed, using correlation analysis method. A positive correlation
of an exponential nature was found to be growing in line with temporal development
of episode.
PMID: 1166758 [PubMed - indexed for MEDLINE]
39: Act Nerv Super (Praha). 1975;17(4):291-2.
Proceedings: Interhemispheral difference in the drug effect on the EEG.
Hynek K, Tosovsky J, Susova J, Faber J.
PMID: 1221803 [PubMed - indexed for MEDLINE]
40: Acta Univ Carol Med Monogr. 1975;(64):1-78.
Formal aspects of vigilance during petit mal paroxysm.
Faber J.
Relationship between amplitude and interval of healthy and epileptic children's
alpha activity was investigated. A directly proportional, though non-linear
(mostly exponential) correlation was found, i. e. the higher the waves, the
wider their are, and vice versa, the lower, the narrower. This is a well-known
feature of clinical electroencephalography, representing a good organization
of EEG elements and, in terms of physiology, suggesting good "co-operation" of
the recruitment process excitation and inhibition. Low interval values are
matched by equally low amplitude values while inhibition is adequate. At higher
interval values, amplitude is seen rising rapidly, inhibition is inadequate
resulting in "paroxysmal" alpha activity which is occasionally found
assuming the nature of spike and slow wave activity. The appearance of such
principal changes in the recruitment process is abrupt, but a certain part
of the changes often fails to manifest itself in the EEG curve. Epileptic children's
alpha activity has a relatively higher amplitude, slower rhythm and a more
regular regulation of amplitudes and intervals as well as that of their ratio.
This is in line with the tendency toward hypersynchrony of EEG elements in
epileptics. Epileptic spike and wave activity has an opposite sense of regulation
as to the relationship of spike amplitudes and intervals, the principle being:
the higher the spikes, the shorter the intervals between them. Apart from frequency,
amplitude and angular velocity, that is another substantial difference between
alpha activity physiological synchronization in vigilance and pathological
spike hypersynchronization in petit mal seizure. Changes in vigilance seem
to be in agreement with this phenomenon. The nature of recruitment process
regulation (given in type of function) appears to be very stable, often remaining
unchanged even under pathological conditions. Thus e. g. aplha wave recruitment
during vigilance and spike recruitment during seizure are linear in either
case. But while in alpha activity the amplitude-interval ratio is directly
proportional, in spikes the proportionality is inverse. Alpha activity appears
to be accompanied by inhibitory processes, spikes by excitatory processes.
The number of active neurones and their synchronization in the course of spike-wave
episodes is higher than during alpha activity. For that reason, in the course
of epileptic recruitment process, expedient temporal-spatial integration of
neuronal activity decreases to be superceded by simplified hypersynchronous
reverberation with lower analytical-synthetic ability and lower reflectivity.
PMID: 811100 [PubMed - indexed for MEDLINE]
41: Act Nerv Super (Praha). 1974 May;16(2):134-40.
EEG and vigilance during the petit mal attack.
Faber J, Tosovsky J, Taichmanova Z, Taberyova M.
PMID: 4213108 [PubMed - indexed for MEDLINE]
42: Act Nerv Super (Praha). 1974 Mar;16(1):52-3.
The influence of imipramine, dexphenmetrazine and amphetamine-sulphate
on the composition of diurnal sleep of narcoleptics.
Roth B, Faber J, Nevsimalova S, Tosovsky J.
PMID: 4454940 [PubMed - indexed for MEDLINE]
43: Act Nerv Super (Praha). 1974;16(4):258-9.
Proceedings: Factor analysis of EEG of healthy subjects given no drugs
and a combination of diazepam and methylphenidate.
Faber J, Tosovsky J, Hynek K.
PMID: 4451002 [PubMed - indexed for MEDLINE]
44: Act Nerv Super (Praha). 1974;16(4):257-8.
Proceedings: The effect of combination of methylphenidate and diazepam
on the EEG and its evaluation by means of discriminant analysis.
Hynek K, Faber J, Tosovsky J, Cerny M.
PMID: 4451001 [PubMed - indexed for MEDLINE]
45: Act Nerv Super (Praha). 1974;16(4):256-7.
Proceedings: Discrimination analysis of the electroencephalogram of healthy
volunteers given drugs and of patients with brain tumours.
Tosovsky J, Faber J, Hynek K.
PMID: 4451000 [PubMed - indexed for MEDLINE]
46: Act Nerv Super (Praha). 1973 Aug;15(3):177.
Application of the periodogram to human alpha activity.
Tosovsky J, Faber J, Hynek K.
PMID: 4797658 [PubMed - indexed for MEDLINE]
47: Act Nerv Super (Praha). 1973 Aug;15(3):222-5.
Height-width correlation of alpha waves in children.
Faber J, Vedralova J, Psenickova J, Hynek K, Tajchmanova Z, Tosovsky J.
PMID: 4769144 [PubMed - indexed for MEDLINE]
48: Act Nerv Super (Praha). 1973 Aug;15(3):178-9.
The application of discrimination analysis for distinguishing pathological
foci in the electroencephalogram of benign and malign tumours.
Faber J, Tosovsky J, Stein J, Mejsnerova B.
PMID: 4769140 [PubMed - indexed for MEDLINE]
49: Fysiatr Revmatol Vestn. 1973 Aug;51(4):245-7.
[Unusual case of coincidence of progressive arthritis and spinal tumor]
[Article in Czech]
Vymazal J, Tuhacek M, Simkova L, Faber J.
PMID: 4737058 [PubMed - indexed for MEDLINE]
50: Act Nerv Super (Praha). 1973 May;15(2):98-9.
Influence of the treatment with clozapine on the EEG of schizophrenics.
Hynek K, Faltus F, Zemek P, Faber J.
PMID: 4752686 [PubMed - indexed for MEDLINE]
51: Cesk Neurol. 1973 Mar;36(2):108-13.
[Method of averages and functions used in differentiating the subclinical
and clinical petit mal paroxysms]
[Article in Czech]
Faber J, Tosovsky J, Taichmanova Z, Tuhacek M, Mestan J.
PMID: 4631982 [PubMed - indexed for MEDLINE]
52: Act Nerv Super (Praha). 1972;14(1):61-3.
Statistical and mathematical analysis of clinical and sub-clinical paroxysms
petit mal.
Faber J, Tosovsky J, Mestan J, Tuhacek M.
PMID: 4623358 [PubMed - indexed for MEDLINE]
53: Act Nerv Super (Praha). 1972;14(1):35-9.
A clinical and polygraphic study of the effect of a new imidazo-quinazoline
derivative in narcolepsy-cataplexy. The relationship between the antidepressant
and anticataplectic effects of the drug.
Roth B, Faber J, Nevsimalova S.
PMID: 4336749 [PubMed - indexed for MEDLINE]
54: Cesk Neurol. 1971 Jul;34(4):191-6.
[Palencephalography in aneurysms and cerebral arteriovenous malformations]
[Article in Czech]
Tuhacek M, Faber J.
PMID: 5567445 [PubMed - indexed for MEDLINE]
55: Cesk Pediatr. 1971 May;26(5):230-2.
[Mathematical analysis of paroxysms of petit mal]
[Article in Czech]
Faber J, Tuhacek M, Lehovsky M, Tosovsky J.
PMID: 4997732 [PubMed - indexed for MEDLINE]
56: Schweiz Arch Neurol Neurochir Psychiatr. 1971;108(2):251-60.
The influence of imipramine, dexphenmetrazine and amphetaminsulphate upon
the clinical and polygraphic picture of narcolepsy-cataplexy.
Roth B, Faber J, Nevsimalova S, Tosovsky J.
PMID: 4330752 [PubMed - indexed for MEDLINE]
57: Cesk Neurol. 1970 Nov;33(6):296-301.
[Synchronization of EEG activity and respiration]
[Article in Czech]
Faber J, Tuhacek M, Mestan J.
PMID: 5489332 [PubMed - indexed for MEDLINE]
58: Cesk Neurol. 1970 Jan;33(1):29-35.
[Effect of imipramine, dexphenmetrazine and amphetamine sulfate on synchronous
and paradoxical sleep in narcolepsy-cataplexy. A polygraphic study]
[Article in Czech]
Roth B, Faber J, Nevsimalova S, Tosovsky J.
PMID: 4312702 [PubMed - indexed for MEDLINE]
59: Cesk Neurol. 1969 Jul;32(4):189-92.
[Palencephalography in expansive intracranial processes]
[Article in Czech]
Stary O, Faber J, Tuhacek M.
PMID: 5795006 [PubMed - indexed for MEDLINE]
60: Cesk Neurol. 1969 May;32(3):113-21.
[Palencephalography. A new examination method]
[Article in Czech]
Stary O, Tuhacek M, Faber J.
PMID: 5770737 [PubMed - indexed for MEDLINE]
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